<div style="margin-bottom: 10px;">
                      <a href=https://www.sec.gov/Archives/edgar/data/1427925/000143774923006898/acrx20230315_8k.htm>Download 8-K Special Filing Report</a>
                    </div>
                    <div>
                      <a href=https://www.sec.gov/Archives/edgar/data/1427925/000143774923006898/0001437749-23-006898-index.htm>Original filing index</a>
                    </div>

XBRL TAXONOMY EXTENSION DEFINITION LINKBASE

XBRL TAXONOMY EXTENSION PRESENTATION LINKBASE

Form 8-K - Current report - Item 1.01 Item 1.02 Item 9.01

Acelrx Pharmaceuticals Inc

Announcement: ACRX 8-K Special Filing

<div style="margin-bottom: 10px;">
                      <a href=https://www.sec.gov/Archives/edgar/data/1427925/000117266123001030/armistice-acrx123122a1.htm>Download SC 13G/A Special Filing</a>
                    </div>
                    <div>
                      <a href=https://www.sec.gov/Archives/edgar/data/1427925/000117266123001030/0001172661-23-001030-index.htm>Original filing index</a>
                    </div>

Form SC 13G/A - Statement of acquisition of beneficial ownership by individuals: [Amend]

Announcement: ACRX SC 13G/A Statement of acquisition of beneficial ownership by individuals - amendment

<div style="margin-bottom: 10px;">
                          <a href=https://www.sec.gov/Archives/edgar/data/1427925/000143774922029857/acrx20221227_8k.htm>Download 8-K Special Filing Report</a>
                        </div>
                        <div>
                          <a href=https://www.sec.gov/Archives/edgar/data/1427925/000143774922029857/0001437749-22-029857-index.htm>Original filing index</a>
                        </div>

Form 8-K - Current report - Item 8.01 Item 9.01

<div style="margin-bottom: 10px;">
                          <a href=https://www.sec.gov/Archives/edgar/data/1427925/000143774922028437/acrx20221204_8k.htm>Download 8-K Special Filing Report</a>
                        </div>
                        <div>
                          <a href=https://www.sec.gov/Archives/edgar/data/1427925/000143774922028437/0001437749-22-028437-index.htm>Original filing index</a>
                        </div>

<div style="margin-bottom: 10px;">
                          <a href=https://www.sec.gov/Archives/edgar/data/1427925/000143774922027307/acrx20220930_10q.htm>Download 10-Q Quarterly Report</a>
                        </div>
                        <div>
                          <a href=https://www.sec.gov/Archives/edgar/data/1427925/000143774922027307/0001437749-22-027307-index.htm>Original filing index</a>
                        </div>

XBRL TAXONOMY EXTENSION CALCULATION LINKBASE

Form 10-Q - Quarterly report [Sections 13 or 15(d)]

Announcement: ACRX 10-Q Quarterly Report

<div style="margin-bottom: 10px;">
                          <a href=https://www.sec.gov/Archives/edgar/data/1427925/000143774922027267/acrx20221111_8k.htm>Download 8-K Special Filing Report</a>
                        </div>
                        <div>
                          <a href=https://www.sec.gov/Archives/edgar/data/1427925/000143774922027267/0001437749-22-027267-index.htm>Original filing index</a>
                        </div>

Form 8-K - Current report - Item 2.02 Item 9.01